Stability of zopiclone in whole blood Studies from a forensic perspective
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چکیده
............................................................................................................................ 1 POPULÄRVETENSKAPLIG SAMMANFATTNING..................................................... 3 LIST OF PAPERS ................................................................................................................... 5 ABBREVIATIONS................................................................................................................. 6 INTRODUCTION.................................................................................................................. 7 Pre‐analytical conditions............................................................................................... 7 Drug stability................................................................................................................... 7 Design and evaluation of stability experiments....................................................... 9 Stability investigations of drugs................................................................................ 10 Zopiclone........................................................................................................................ 11 Pharmacokinetics .................................................................................................... 12 Pharmacodynamics................................................................................................. 13 Forensic cases........................................................................................................... 14 Analytical methods ................................................................................................. 16 Biological specimens............................................................................................... 17 AIMS OF THESIS ................................................................................................................ 19 Specific aims .................................................................................................................. 19 Paper I ....................................................................................................................... 19 Paper II...................................................................................................................... 19 MATERIALS AND METHODS........................................................................................ 21 Study designs ................................................................................................................ 21 Long‐ and short‐term stability .............................................................................. 21 Freeze‐thaw stability............................................................................................... 22 Processed stability................................................................................................... 22 Degradation ............................................................................................................. 22 Influence of pre‐analytical conditions.................................................................. 22
منابع مشابه
Zopiclone degradation in biological samples Characteristics and consequences in forensic toxicology
.............................................................................................................................. 1 POPULÄRVETENSKAPLIG SAMMANFATTNING............................................................. 3 LIST OF PAPERS...................................................................................................................... 5 ABBREVIATIONS.........................
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